call1 646 569 9193 - US | 02 8014 8290 - AU | 0871 218 7137 - UK

Shopping Cart
Gifts: 3
Products: 0
Total: $0.00
SSL Certificate Authority
  • Never miss a moment again

    Why missing moments with your loved ones when you have the solution at one click distance?
    Stop your worries and share again your special moments.

    More

  • Best packs

    Don't know what is the best ED drug for you?

    Want to try different format of your prefered pills?

    Check our packs selection and try it all.

    See packs

  • The pleasure drug

    Do you want to have more libido?
    Do you want to have overwhelming orgasms and stronger ejaculations?

    Dostinex can make sex better, much better, that`s the reason it is called "The pleasure drug".

    Try Dostinex now.

    More

  • Anti premature ejaculation

    Sometimes things happen much quicker than you would love to.

    Prevent premature ejaculation with our drugs.

    Let the moment last as much as you want.

    More

  • Buy safe and with guarantees

    This site is protected through 256 SSL encryption.
    Secure CC purchase.
    .
    Guaranteed delivery and money back guarantee.
    Privacy on your CC statement. Your satisfacton our goal.

  • Free Shipping

    Free airmail shipping with all our products.
    No hidden costs.

    24-48h drugs shipping, 10-18 days parcel receipt.

    Guaranteed delivery.

Generic Sinemet

Sinemet

Free gift
up to
30 pills

Description

Sinemet (Carbidopa-Levodopa) is a combination of carbidopa and levodopa for the treatment of Parkinson's disease and syndrome.

Category: Others

Active substance: Carbidopa/Levodopa

Delivery to: spain spain
Oct 28th - Nov 06th (9-18 working days) by Airmail
Oct 24th - Oct 31st (5-12 working days) by EMS

  • Product
    Dosage
    PillQty
    Price
    Per pill
    Buy
  • Generic Sinemet 25mg
  • Sinemet
    25mg
    10
    $74.00
    + 4 free pills
    $7.40
  • Sinemet
    25mg
    20
    $114.00
    + 4 free pills
    $5.70
  • Sinemet
    25mg
    50
    $209.99
    + 10 free pills
    $4.20

Generic Sinemet info

Description

Parkinson's disease is a progressive, neurodegenerative disorder of the extrapyramidal nervous system affecting the mobility and control of the skeletal muscular system. Its characteristic features include resting tremor, rigidity, and bradykinetic movements. Symptomatic treatments, such as levodopa therapies, may permit the patient better mobility.

Mechanism of Action

Current evidence indicates that symptoms of Parkinson's disease are related to depletion of dopamine in the corpus striatum. Administration of dopamine is ineffective in the treatment of Parkinson's disease apparently because it does not cross the blood-brain barrier. However, levodopa, the metabolic precursor of dopamine, does cross the blood-brain barrier, and presumably is converted to dopamine in the brain. This is thought to be the mechanism whereby levodopa relieves symptoms of Parkinson's disease.

Pharmacodynamics

When levodopa is administered orally, it is rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system. For this reason, large doses of levodopa are required for adequate therapeutic effect, and these may often be accompanied by nausea and other adverse reactions, some of which are attributable to dopamine formed in extracerebral tissues.

Since levodopa competes with certain amino acids for transport across the gut wall, the absorption of levodopa may be impaired in some patients on a high protein diet.

Carbidopa inhibits decarboxylation of peripheral levodopa. It does not cross the blood-brain barrier and does not affect the metabolism of levodopa within the central nervous system.

The incidence of levodopa-induced nausea and vomiting is less with SINEMET than with levodopa. In many patients, this reduction in nausea and vomiting will permit more rapid dosage titration.

Since its decarboxylase inhibiting activity is limited to extracerebral tissues, administration of carbidopa with levodopa makes more levodopa available for transport to the brain.

Pharmacokinetics

Carbidopa reduces the amount of levodopa required to produce a given response by about 75% and, when administered with levodopa, increases both plasma levels and the plasma half-life of levodopa, and decreases plasma and urinary dopamine and homovanillic acid.

The plasma half-life of levodopa is about 50 minutes, without carbidopa. When carbidopa and levodopa are administered together, the half-life of levodopa is increased to about 1.5 hours. At steady state, the bioavailability of carbidopa from SINEMET tablets is approximately 99% relative to the concomitant administration of carbidopa and levodopa.

In clinical pharmacologic studies, simultaneous administration of carbidopa and levodopa produced greater urinary excretion of levodopa in proportion to the excretion of dopamine than administration of the two drugs at separate times.

Pyridoxine hydrochloride (vitamin B6), in oral doses of 10 mg to 25 mg, may reverse the effects of levodopa by increasing the rate of aromatic amino acid decarboxylation. Carbidopa inhibits this action of pyridoxine; therefore, SINEMET can be given to patients receiving supplemental pyridoxine (vitamin B6).

Usage

Sinemet uses are primarily concerned with treating Parkinson's disease and Parkinson-like symptoms. This eMedTV page takes an in-depth look what Sinemet is used for, including how it works to increase dopamine levels and possible off-label uses.

Sinemet Dosage

The typical recommended starting Sinemet dosage is 25-100 mg three times daily. As this eMedTV article explains, the recommended dose will vary, depending on factors such how you respond to Sinemet and other medications you are taking.
Sinemet Drug Interactions

 Medicines that may cause Sinemet drug interactions include blood pressure medicines and antipsychotic drugs. This eMedTV segment lists other medicines that may interact with Sinemet and explains what can happen when these medicines are combined.

Warnings

Sinemet Warnings and Precautions

This eMedTV page outlines several important Sinemet warnings and precautions. For example, you should not use the drug if you have narrow-angle glaucoma or a history of melanoma. This page also explains what to tell your doctor before taking it.
Sinemet Overdose

This eMedTV resource explains that vomiting, confusion, and a rapid heart rate are possible effects of a Sinemet (carbidopa-levodopa) overdose. This page lists other symptoms that may occur and describes various treatment options that are available.

Sinemet and Pregnancy

This page from the eMedTV Web site explains that information from animal studies on Sinemet (carbidopa-levodopa) and pregnancy indicates that the drug may not be safe for pregnant women. For example, the drug may increase the risk of birth defects.

Sinemet and Breastfeeding

This eMedTV Web article explains that Sinemet (carbidopa-levodopa) does pass through breast milk. As a result, it may negatively affect a woman's ability to breastfeed. It is not known what effects the medication might have on a nursing infant.

Side effects

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Sinemet:
 
Confusion; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; increased sweating; loss of appetite; nausea; taste changes; trouble sleeping; upset stomach; urinary tract infection; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur when using Sinemet:
 
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in vomit; chest pain; confusion; depression; fast or irregular heartbeat; fever; hallucinations; mental or mood changes; muscle pain or unusual stiffness; new or increased involuntary movements; severe abdominal pain; severe lightheadedness or fainting; sore throat; thoughts of suicide; unexplained fever or sweating; unusual bruising or bleeding; unusual or painful movements or spasms of the face, eyelids, mouth, tongue, arms, hands, or legs; vision changes (blurred or double vision); yellowing of the skin or eyes.
 
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Package example

Your order will be packed safely and secure and dispatched within 24hours. THis is how your parcel will look like, the images are photographs of real shipments. It has the size of a normal protected envelope and it does not disclose its contents.

Track your order

Buy risk free

Total Guarantee

We will refund your money if your meds do not arrive or you do not like our products

Free Reshipping

Free reshipping if there is any problem with the delivery

Total Privacy

No pharmacy products reference in your credit card statement or on our package.

Total Security

Your personal information will not be avaliable to anyone. We do not share it. We keep the highest security and practices standards.

Video testimonials

  • Rob, Cleveland, Ohio, USA.
  • Tim, St Petersburg, Florida, USA.
  • Amanda, Wichita, Kansas, USA.
  • Fred, Racine, Wisconsin, USA.
Oct 28th - Nov 06th by Airmail
No signature is required on delivery
Saturday
19
Oct
Delivery dates if ordered today Thu
24
Oct
Fri
25
Oct
Sat
26
Oct
Sun
27
Oct
Mon
28
Oct
Tue
29
Oct
Wed
30
Oct
Thu
31
Oct
Fri
01
Nov
Sat
02
Nov
Sun
03
Nov
Mon
04
Nov
Tue
05
Nov
Wed
06
Nov
Oct 24th - Oct 31st by EMS
Signature is required on delivery
Country Shipping Method Tracking Delivery time Delivery to Price
spain Registered Airmail Delivery Report only (where available). Each parcel is dispatched with unique Tracking ID which may be later used via Track-Trace service Oct 28th - Nov 06th
9-18 working days
Mailbox FREE
EMS Tracking report (where available). Each parcel is dispatched with unique Tracking ID which may be later used via Track-Trace service Oct 24th - Oct 31st 5-12 working days Mailbox $29.99 each 120 pills

Customer reviews

Thank you. Thank you for caring. Thank you for thinking of your customers. Thank you for providing an American like myself access to affordable health care. I can't afford this monthly RX where I live in California. My individual health insurance does not cover it. You were the best tip I got last year in regards to health care services. I can't thank you enough.

Quality of products & services: 5 stars out of 55 stars out of 5

John B. from Albuquerque, UNITED STATES
July 14th 2012



With the options they gave me I saved about 80% over the local pharmacy prices I would have paid, was easy to order with clear instructions on how to provide the required prescription, payment process was secure and the product delivered as advertised. Very satisfied and I highly recommend this online pharmacy.


Quality of products & services: 5 stars out of 55 stars out of 5

Mike from NY, UNITED STATES
July 13th 2012

Thanks for helping me afford a med that would otherwise be unaffordable from U.S. pharmacies. I experienced no issues with your shipment getting to me. Happy repeat customer here.

Quality of products & services: 5 stars out of 55 stars out of 5

Peter from Lexington, UNITED STATES
July 12th 2012

very easy! Cannot beat the prices-amazing!!!! This site has literally saved my life!!! I could not buy my prescriptions in the U.S. without insurance. You are for real and was a GREAT FIND!! Thank You!!!

Quality of products & services: 5 stars out of 55 stars out of 5

Jennifer from Dallas, UNITED STATES
July 12th 2012

I love this site! Best customer service experience I've ever had shopping online! I absolutely agree with this! Ibwill continue to business with you guys!!! My last order was lost by the post iffice and u shipped me a replacement immediately freebof charge! I greatly apprecuate that and I wont do business with anyonenelse because you treated me so well. thanks again!

Quality of products & services: 5 stars out of 55 stars out of 5

Thomas from Bridgeport, UNITED STATES
July 11th 2012

View all reviews

Visa Visa electron MasterCard Maestro

All VISA and Mastercard Credit Cards (Debit, Credit, Prepaid & Gift cards) are accepted. No credit card? Buy with cash with